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Article

T cell phenotype and clonality changes in myeloma patients with short overall survival.

JCI insight - 9 Jun 2025

Behsen Alenka Djarmila, Vandsemb Esten Nymoen, Slørdahl Tobias Schmidt, Dybkær Karen, Jakobsen Maja Zimmer, Kashif Muhammad, Lund Johan, Luong Vincent, Olsnes Astrid Marta, Waage Anders, Sponaas Anne Marit, Misund Kristine

Abstract excerpt

Overall survival (OS) in multiple myeloma (MM) varies between a couple of months to more than 20 years, influenced by tumor characteristics, the tumor microenvironment (TME), and patient factors such as age and frailty. We analyzed sequential BM samples from 45 MM patients with OS less than 3 years versus more than 8 years using mass cytometry and bulk TCRβ sequencing. Patients with long OS demonstrated stability...

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Share to Aged, 80 and over
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Multiple Myeloma

Share to Programmed Cell Death 1 Receptor

Share to Receptors, Antigen, T-Cell, alpha-beta

Share to T-Lymphocytes

Share to T-Lymphocytes, Regulatory

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Source

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Identifiers

PMID: 40299757
DOI: 10.1172/jci.insight.181096
PMCID: PMC12220974

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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