Article

Single-cell transcriptional analysis of the immune tumour microenvironment during myeloma disease evolution

2021-10-24

Abstract excerpt

Multiple myeloma is universally preceded by a premalignant disease state. However, efforts to develop preventative therapeutic strategies are hindered by an incomplete understanding of the immune mechanisms associated with progression. Using single-cell RNA-sequencing, we profiled 104,880 cells derived from the bone marrow of Vκ*MYC mice across the myeloma progression spectrum, of which 97,720 were identified as n...

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Literature Corpus work: 8cfe88f3-82a7-5f16-83d7-af2daef5d701
DOI: 10.1101/2021.10.22.464971

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