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Article

Reconciling 'the new epidemiology' with an evolutionary genetic basis for schizophrenia.

Medical hypotheses - 1 Mar 2009

Burns Jonathan Kenneth

Abstract excerpt

Recent epidemiological findings of variable incidence and prevalence pose a problem for evolutionary genetic analyses of schizophrenia. The author rejects models of psychosis based on balanced polymorphism and develops an alternative evolutionary model incorporating concepts of anatagonistic pleiotropy, 'cliff-edged fitness' and gene-environment interactions. In essence, genes for psychosis are considered as...

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PMID: 19028022
DOI: 10.1016/j.mehy.2008.09.046

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