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Article

Testing the antagonistic pleiotropy model of schizophrenia susceptibility by analysis of DAOA, PPP1R1B, and APOL1 genes.

Psychiatry research - 30 Sept 2010

Carrera Noa, Arrojo Manuel, Paz Eduardo, Ramos-Ríos Ramón, Agra Santiago, Páramo Mario, Brenlla Julio, Costas Javier

Abstract excerpt

Schizophrenia is a common disease associated with reduced fertility. Therefore, the existence of common susceptibility alleles not removed by natural selection may be considered an evolutionary paradox. The antagonistic pleiotropy model, proposed to explain this paradox, states that an allele may be common because of its overall selective advantage, in spite of deleterious effects on specific traits. Recent work...

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Source

Identifiers

PMID: 20483474
DOI: 10.1016/j.psychres.2009.05.014

Genes

APOL1
DAOA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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