Article
Apolipoprotein E isoforms differentially affect LCAT-dependent cholesterol esterification.
Atherosclerosis - 1 Oct 2023
Vitali Cecilia, Pavanello Chiara, Turri Marta, Lund-Katz Sissel, Phillips Michael C, Catapano Alberico Luigi, Baragetti Andrea, Norata Giuseppe Danilo, Veglia Fabrizio, Calabresi Laura
Abstract excerpt
BACKGROUND AND AIMS: LCAT esterifies cholesterol in both HDL (α-activity) and apoB-containing lipoproteins (β-activity). The main activator of LCAT β-activity is apoE, which in humans exists in 3 main different isoforms (E2, E3 and E4). Here, to gather insights into the potential role of LCAT in apoB-containing lipoprotein metabolism, we investigated the ability of apoE isoforms to promote LCAT-mediated...
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