Article
Lipoprotein(a) Mass Levels Increase Significantly According to APOE Genotype: An Analysis of 431 239 Patients.
Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2017
Moriarty Patrick M, Varvel Stephen A, Gordts Philip L S M, McConnell Joseph P, Tsimikas Sotirios
Abstract excerpt
OBJECTIVE: Lipoprotein(a) [Lp(a)] levels are genetically determined by hepatocyte apolipoprotein(a) synthesis, but catabolic pathways also influence circulating levels. APOE genotypes have different affinities for the low-density lipoprotein (LDL) receptor and LDL-related protein-1, with ε2 havin...
Topics
- Adult
- Aged
- Apolipoprotein B-100
- Apolipoproteins E
- Biomarkers
- Cholesterol, LDL
- Female
- Gene Frequency
- Genetic Association Studies
- Genotype
- Humans
- Lipoprotein(a)
- Male
- Middle Aged
- Phenotype