Article

Multi-scale spatial modeling of immune cell distributions enables survival prediction in primary central nervous system lymphoma

2022-09-28

Abstract excerpt

To understand the clinical significance of the tumor microenvironment (TME), it is essential to study the interactions between malignant and non-malignant cells in clinical specimens. Here, we established a computational framework for a multiplex imaging system to comprehensively characterize spatial contexts of the TME at multiple scales, including close and long-distance spatial interactions between cell type pa...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 816c5db5-fb08-5682-acba-92fc0b4a988e
DOI: 10.1101/2022.09.27.509403

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multi-scale spatial modeling of immune cell distributions enables survival prediction in primary central nervous system lymphomaDOI 10.1101/2022.09.27.509403Read

Spatial transcriptomics unveils immune cellular ecosystems associated with patient survival in diffuse large B-cell lymphomaSemantic proximity Read

Delineating spatial cell-cell interactions in the solid tumour microenvironment through the lens of highly multiplexed imagingSemantic proximity Read

Single Cell Spatial Analysis and Biomarker Discovery in Hodgkin LymphomaSemantic proximity Read

Spatial Analysis of Malignant-Immune Cell Interactions in the Tumor Microenvironment Using Topological Data AnalysisSemantic proximity Read

Single-cell spatial analysis of tumor immune architecture in diffuse large B-cell lymphomaSemantic proximity Read

Single-cell spatial analysis of tumor immune architecture in diffuse large B cell lymphomaSemantic proximity Read

Prognostic significance of spatial immune profiles in human solid cancersSemantic proximity Read

Spatial Phenotyping of Nodular Lymphocyte Predominant Hodgkin Lymphoma and T-cell/Histiocyte-Rich Large B-cell LymphomaSemantic proximity Read

Unveiling spatial complexity in solid tumor immune microenvironments through multiplexed imaging.Semantic proximity Read

MICRON learns outcome-associated representations of spatial immune microenvironmentsSemantic proximity Read

Spatially-resolved transcriptomics reveal macrophage heterogeneity and prognostic significance in diffuse large B-cell lymphomaSemantic proximity Read

SPACE-GM: geometric deep learning of disease-associated microenvironments from multiplex spatial protein profilesSemantic proximity Read