Article

Deep Spatial Sequencing Revealing Differential Immune Responses in Human Hepatocellular Carcinoma

2025-03-29

Abstract excerpt

Hepatocellular carcinoma (HCC) is one of the most lethal cancers for humans. HCC is highly heterogeneous. In this study, we performed ultra-depth (∼1 million reads per spot) spatial sequencing on a case of HCC. Sixteen distinct spatial expression clusters were identified. Each of these clusters was spatially contiguous and had distinct gene expression patterns. In contrast, benign liver tissues showed minimal hete...

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Literature Corpus work: f4ac046d-e5db-5fe9-911c-8c21df62431b
DOI: 10.1101/2025.03.25.645292

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