A flexible systems analysis pipeline for elucidating spatial relationships in the tumor microenvironment linked with cellular phenotypes and patient-level features.

Abstract excerpt

Introduction: Quantitative investigation of how the spatial organization of cells within the tumor microenvironment associates with disease progression, patient outcomes, and that cell's phenotypic state remains a key challenge in cancer biology. High-dimensional multiplexed imaging offers an opportunity to explore these relationships at single-cell resolution. Methods: We developed a computational pipeline to...

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