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Article

A SARS-CoV-2 variant-induced NTD-targeting antibody enhances viral infection via a distinctive binding mode.

PLoS pathogens - 1 Feb 2026

Li Wenting, Liu Congcong, Li Yaning, Gui Qi, Cheng Lin, Fan Qing, Zhou Bing, Wang Haiyan, Ge Xiangyang, Zhang Zheng, Yan Renhong, Ju Bin

Abstract excerpt

SARS-CoV-2 infection elicits both neutralizing and non-neutralizing monoclonal antibodies (mAbs), primarily targeting to the N-terminal domain (NTD), receptor-binding domain (RBD), and S2 subunit of the spike protein. Notably, a unique subset of NTD-targeting mAbs isolated from prototype Wuhan-Hu-1 strain infected donors displayed a capacity of facilitating the viral infection independent of the fragment...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41666181
DOI: 10.1371/journal.ppat.1013828
PMCID: PMC12890138

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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