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Article

DNA mutations mediate microevolution between host-adapted forms of the pathogenic fungus Cryptococcus neoformans.

PLoS pathogens - 1 Jan 2012

Magditch Denise A, Liu Tong-Bao, Xue Chaoyang, Idnurm Alexander

Abstract excerpt

The disease cryptococcosis, caused by the fungus Cryptococcus neoformans, is acquired directly from environmental exposure rather than transmitted person-to-person. One explanation for the pathogenicity of this species is that interactions with environmental predators select for virulence. However, co-incubation of C. neoformans with amoeba can cause a "switch" from the normal yeast morphology to a pseudohyphal...

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Identifiers

PMID: 23055925
DOI: 10.1371/journal.ppat.1002936
PMCID: PMC3464208

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Source receipt: pubmed, retrieved 7 Sept 2026.

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