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Article

Blocking of Tim-3 Ameliorates Spinal Cord Ischemia-Reperfusion Injury Through Inhibiting Neuroinflammation and Promoting M1-to-M2 Phenotypic Polarization of Microglia.

Immunity, inflammation and disease - 1 Dec 2024

Li Zhenxing, Zhou Binbin, Chen Guanghui, Yang Xiangyu, Su Han, Li Bolin

Abstract excerpt

BACKGROUND: Blocking of Tim-3 exerts therapeutic effects in a series of ischemia-reperfusion injury (IRI). METHODS: In this work, a cross-clamped aortic arch was conducted to establish SCIRI rat model. Besides, rat spinal microglia was subjected to OGD/R to mimic I/R-like conditions in vitro. The in vivo and in vitro therapeutic effects of Tim-3 antibody in SCIRI were investigated from these aspects: neuronal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39641284
DOI: 10.1002/iid3.70084
PMCID: PMC11621861

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