Article
Roles of programmed death protein 1/programmed death-ligand 1 in secondary brain injury after intracerebral hemorrhage in rats: selective modulation of microglia polarization to anti-inflammatory phenotype.
Journal of neuroinflammation - 14 Feb 2017
Wu Jie, Sun Liang, Li Haiying, Shen Haitao, Zhai Weiwei, Yu Zhengquan, Chen Gang
Abstract excerpt
BACKGROUND: Microglia and its polarization play critical roles in intracerebral hemorrhage-induced secondary brain injury. Programmed death protein 1/programmed death-ligand 1 has been reported to regulate neuroimmune cell functions. Signal transducers and activators of transcription 1 participate in microglia polarization, and programmed death protein 1/programmed death-ligand 1 could regulate the activation of...
Topics
- Animals
- B7-H1 Antigen
- Brain Injuries
- Cell Death
- Cell Polarity
- Cerebral Hemorrhage
- Male
- Microglia
- Phenotype
- Programmed Cell Death 1 Receptor