Article

Altered drug metabolism and increased susceptibility to fatty liver disease in myotonic dystrophy

2021-04-06

Abstract excerpt

Myotonic Dystrophy type 1 (DM1), a prevalent muscular dystrophy affecting 1 in 2800 individuals, is associated with a toxic (CTG) n repeat expansion in the DMPK gene. While DM1 affects multiple systems, recent studies highlight its link to liver pathology, glucose intolerance, and drug sensitivity. Our study focused on liver implications by creating a hepatocyte-specific DM1 mouse model. Expression of toxic RNA...

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Literature Corpus work: dd7e58ee-f129-5ec8-b808-0a3bad33a011
DOI: 10.1101/2021.04.06.438688

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