Article

Hemin-Induced Transient Senescence via DNA Damage Response as Potential Neuroprotective Mechanism during Brain Hemorrhage

2024-07-26

Abstract excerpt

<title>Abstract</title> <p>Intracerebral hemorrhage (ICH) poses acute fatality and long-term neurological risks due to hemin and iron accumulation from hemoglobin breakdown. Our observation that hemin induces DNA double-strand breaks (DSBs), prompting a senescence-like phenotype in neurons, necessitating deeper exploration of cellular responses. Using experimental ICH models and human ICH patient tissue, we eluci...

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Literature Corpus work: 68d41bea-7819-5718-a70b-5a3d14aa9795
DOI: 10.21203/rs.3.rs-4686841/v1

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