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Article

Cellular Senescence Is Associated With Human Retinal Microaneurysm Formation During Aging

1 Jun 2017

Abstract excerpt

Purpose: Microaneurysms are present in healthy old-age human retinas. However, to date, no age-related pathogenic mechanism has been implicated in their formation. Here, cellular senescence, a hallmark of aging and several age-related diseases, has been analyzed in the old-age human retina and in the retina of a progeric mouse. Methods: Retinas were obtained from 17 nondiabetic donors and from mice deficient in...

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PMID: 28570738
DOI: 10.1167/iovs.16-20312

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