Article

Class I HDAC Inhibitor Rescues Synaptic Damage and Neuron Loss in APP-Transfected Cells and APP/Ps1 Mice through the GRIP1/AMPA Pathway

2021-12-03

Abstract excerpt

<title>Abstract</title> <p>As a neurodegenerative disease, Alzheimer's disease (AD) seriously affects the health of older people. It is now known that changes in synapses occur first in the course of disease, perhaps even before the formation of Aβ plaques. Histone deacetylase (HDAC) can mediate the damage of Aβ oligomers to dendritic spines. Therefore, we examined the relationship between HDAC activity and synap...

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Literature Corpus work: 80b21161-8522-5db4-9d75-477a16919f00
DOI: 10.21203/rs.3.rs-1119498/v1

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