Article
Evidence that donors with variant RH genotypes are associated with unexpected Rh antibodies.
Transfusion - 1 Oct 2023
Kirkegaard Julie, Rahorst Lynsi, Burgos Anna, Music Aplenc Lejla, Iqbal Nazia Tabassum, Vege Sunitha, Francis Christine Lomas, Westhoff Connie M
Abstract excerpt
BACKGROUND: We previously reported unexpected Rh antibodies in the plasma of patients with sickle cell disease (SCD) that demonstrated common Rh specificities in the absence of transfusion of RBCs positive for that antigen. We hypothesize that these antibodies might result from transfusion of antigen-negative donor units with variant RH genotypes. METHODS: Plasma testing by tube and IgG gel, extended RBC...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.