Article
Genotyped RhD+ red cells for D-positive patients with sickle cell disease with conventional RHD and unexpected anti-D.
Blood - 7 Nov 2024
Chou Stella T, Mewha Julia, Friedman David F, Lazariu Victoria, Makrm Shaimaa, Ochoa Gorka, Vege Sunitha, Westhoff Connie M
Abstract excerpt
ABSTRACT: Anti-D can occur in D-positive patients who inherit RHD genetic variants encoding partial D antigen expression, but unexpected anti-D is also found in the plasma of patients with sickle cell disease who have conventional RHD gene(s) and are transfused with units from Black donors. These anti-D are likely stimulated by variant Rh expressed on donor cells; however, patients with anti-D, regardless of...
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