Article
RH genotyping in a sickle cell disease patient contributing to hematopoietic stem cell transplantation donor selection and management.
Blood - 14 Oct 2010
Fasano Ross M, Monaco Alessandro, Meier Emily Riehm, Pary Philippe, Lee-Stroka A Hallie, Otridge John, Klein Harvey G, Marincola Francesco M, Kamani Naynesh R, Luban Naomi L C, Stroncek David, Flegel Willy A
Abstract excerpt
African individuals harbor molecular RH variants, which permit alloantibody formation to high-prevalence Rh antigens after transfusions. Genotyping identifies such RH variants, which are often missed by serologic blood group typing. Comprehensive molecular blood group analysis using 3 genotyping platforms, nucleotide sequencing, and serologic evaluation was performed on a 7-year-old African male with sickle cell...
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