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Investigation of germline variants in Bahraini women with breast cancer using next-generation sequencing based-multigene panel.

PloS one - 1 Jan 2023

Al-Kafaji Ghada, Jassim Ghufran, AlHajeri Amani, Alawadhi Amna Mohamed Tayeb, Fida Mariam, Sahin Ibrahim, Alali Faisal, Fadel Elias

Abstract excerpt

Germline variants in BRCA1 and BRCA2 (BRCA1/2) genes are the most common cause of hereditary breast cancer. However, a significant number of cases are not linked to these two genes and additional high-, moderate- and low-penetrance genes have been identified in breast cancer. The advent of next-generation sequencing (NGS) allowed simultaneous sequencing of multiple cancer-susceptibility genes and prompted...

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PMID: 37656691
DOI: 10.1371/journal.pone.0291015
PMCID: PMC10473515

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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