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Multigene panel analysis identified germline mutations of DNA repair genes in breast and ovarian cancer

12 May 2015

Abstract excerpt

Approximately 5-10% of all breast and/or ovarian cancer cases are considered as inherited. BRCA1 and BRCA2 tumor suppressor genes account for a high penetrance of hereditary cases, but familial cases without mutations in these genes can also occur. Despite their low penetrance, other hereditary cancer-related genes are known to be associated with breast and ovarian cancer risk. However, the extent to which these...

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PMID: 26436112
DOI: 10.1002/mgg3.157

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