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Next generation sequencing analysis of BRCA1 and BRCA2 identifies novel variations in breast cancer.

Life sciences - 15 Nov 2020

Yildiz Tacar Seher, Bozgeyik Esra, Seber Erdogan Selcuk, Yetisyigit Tarkan, Tozkir Hilmi, Avci Okan, Arslan Ahmet

Abstract excerpt

Mutations in two major breast cancer susceptibility genes, BRCA1 and BRCA2, have been identified to be the most important predisposing factors for the development of breast cancer. Thus, BRCA1/2 testing is a well-established method of choice for the assessment of developing breast cancer. Accordingly, here we aimed to report novel BRCA1/2 variations and distribution of previously known mutations and their...

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PMID: 32846166
DOI: 10.1016/j.lfs.2020.118334

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