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Article

Multi-Gene Mutation Profiling by Targeted Next-Generation Sequencing in Premenopausal Breast Cancer.

Genes - 29 Jul 2022

Zografos Eleni, Andrikopoulou Angeliki, Papatheodoridi Alkistis Maria, Kaparelou Maria, Bletsa Garyfalia, Liontos Michalis, Dimopoulos Meletios-Athanasios, Zagouri Flora

Abstract excerpt

Breast cancer has distinct etiology, prognoses, and clinical outcomes at premenopausal ages. Determination of the frequency of germline and somatic mutations will refine our understanding of the genetic contribution to premenopausal breast cancer susceptibility. We applied a comprehensive next generation sequencing-based approach to analyze blood and/or tissue samples of 54 premenopausal breast cancer patients...

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Identifiers

PMID: 36011273
DOI: 10.3390/genes13081362
PMCID: PMC9407588

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