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Screening of BRCA1/2 variants in Mauritanian breast cancer patients.

BMC cancer - 20 Jul 2022

Brahim Selma Mohamed, Zein Ekht Elbenina, Bonnet Crystel, Hamed Cheikh Tijani, Salame Malak, Zein Mohamed Vall, Khyatti Meriem, Tolba Ahmedou, Houmeida Ahmed

Abstract excerpt

BACKGROUND AND STUDY AIM: Carrying a pathogenic BRCA1/2 variant increases greatly young women's risk of developing breast cancer (BC). This study aimed to provide the first genetic data on BC in Mauritania. METHODS: Using NGS based screening; we searched for BRCA1/2 variants in DNA samples from 137 patients diagnosed for hereditary BC. RESULTS: We identified 16 pathogenic or likely pathogenic (PV) variants...

Topics

BRCA1 Protein
BRCA2 Protein
Breast Neoplasms
Early Detection of Cancer
Female
Genetic Predisposition to Disease
Germ-Line Mutation
Humans
Mauritania
Triple Negative Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35858847
DOI: 10.1186/s12885-022-09903-8
PMCID: PMC9301826

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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