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Article

Mitochondrial phenotypes in purified human immune cell subtypes and cell mixtures.

eLife - 26 Oct 2021

Rausser Shannon, Trumpff Caroline, McGill Marlon A, Junker Alex, Wang Wei, Ho Siu-Hong, Mitchell Anika, Karan Kalpita R, Monk Catherine, Segerstrom Suzanne C, Reed Rebecca G, Picard Martin

Abstract excerpt

Using a high-throughput mitochondrial phenotyping platform to quantify multiple mitochondrial features among molecularly defined immune cell subtypes, we quantify the natural variation in mitochondrial DNA copy number (mtDNAcn), citrate synthase, and respiratory chain enzymatic activities in human neutrophils, monocytes, B cells, and naïve and memory T lymphocyte subtypes. In mixed peripheral blood mononuclear...

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Identifiers

PMID: 34698636
DOI: 10.7554/eLife.70899
PMCID: PMC8612706

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