Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Improved tropoelastin synthesis in the skin by codon optimization and nucleotide modification of tropoelastin-encoding synthetic mRNA

2 Aug 2023

Abstract excerpt

Loss of elastin due to aging, disease, or injury can lead to impaired tissue function. In this study, de novo tropoelastin (TE) synthesis is investigated in vitro and in vivo using different TE-encoding synthetic mRNA variants after codon optimization and nucleotide modification. Codon optimization shows a strong effect on protein synthesis without affecting cell viability in vitro , whereas nucleotide...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules Research
Share to Connective tissue disorders research
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37650117
DOI: 10.1016/j.omtn.2023.07.035

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Improved tropoelastin synthesis in the skin by codon optimization and nucleotide modification of tropoelastin-encoding synthetic mRNAPMID 37650117Read ↗

De Novo Synthesis of Elastin by Exogenous Delivery of Synthetic Modified mRNA into Skin and Elastin-Deficient CellsSemantic proximity Read ↗

A synthetic elastic protein as molecular prosthetic candidate to strengthen vascular wall elasticitySemantic proximity Read ↗

Dissection of human tropoelastin: Supramolecular organization of polypeptide sequences coded by particular exonsSemantic proximity Read ↗

Synthetic mRNAs; Their Analogue Caps and Contribution to DiseaseSemantic proximity Read ↗

Elastin-Like Polypeptides for Biomedical ApplicationsSemantic proximity Read ↗

Generation of a tropoelastin mRNA variant by alternative polyadenylation site selection in sun-damaged human skin and ultraviolet B-irradiated fibroblasts.Semantic proximity Read ↗

Induction of Angiogenesis by a Fragment of Human Tyrosyl-tRNA SynthetaseSemantic proximity Read ↗

A Synthetic E7 Gene of Human Papillomavirus Type 16 That Yields Enhanced Expression of the Protein in Mammalian Cells and Is Useful for DNA Immunization StudiesSemantic proximity Read ↗

A human aminoacyl-tRNA synthetase as a regulator of angiogenesisSemantic proximity Read ↗

Elastin-derived peptides enhance angiogenesis by promoting endothelial cell migration and tubulogenesis through upregulation of MT1-MMP.Semantic proximity Read ↗

Structural determinants of cross-linking and hydrophobic domains for self-assembly of elastin-like polypeptides.Semantic proximity Read ↗

Oxidation, cross-linking, and insolubilization of recombinant tropoelastin by purified lysyl oxidaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.