Article
Generation of a tropoelastin mRNA variant by alternative polyadenylation site selection in sun-damaged human skin and ultraviolet B-irradiated fibroblasts.
Biochemical and biophysical research communications - 8 May 1998
Schwartz E, Gelfand J M, Mauch J C, Kligman L H
Abstract excerpt
The goal of this research was to delineate the post-transcriptional mechanisms responsible for the increased elastin synthesis characteristic of sundamaged skin. In this study, a unique molecular variant of the tropoelastin mRNA transcript was identified in human sundamaged skin that was derived...
Topics
- Aged
- Animals
- Base Sequence
- Binding Sites
- DNA Primers
- Female
- Fibroblasts
- Genetic Variation
- Humans
- In Vitro Techniques
- Male
- Mice
- Mice, Hairless