Article
Frequent ZNF217 mutations lead to transcriptional deregulation of interferon signal transduction via altered chromatin accessibility in B cell lymphoma.
Leukemia - 1 Nov 2023
Briest Franziska, Noerenberg Daniel, Hennch Cornelius, Yoshida Kenichi, Hablesreiter Raphael, Nimo Jose, Sasca Daniel, Kirchner Marieluise, Mansouri Larry, Inoue Yoshikage, Wiegand Laura, Staiger Annette M, Casadei Beatrice, Korkolopoulou Penelope, Weiner January, Lopez-Guillermo Armando, Warth Arne, Schneider Tamás, Nagy Ákos, Klapper Wolfram, Hummel Michael, Kanellis George, Anagnostopoulos Ioannis, Mertins Philipp, Bullinger Lars, Rosenquist Richard, Vassilakopoulos Theodoros P, Ott German, Ogawa Seishi, Damm Frederik
Abstract excerpt
Recent exome-wide studies discovered frequent somatic mutations in the epigenetic modifier ZNF217 in primary mediastinal B cell lymphoma (PMBCL) and related disorders. As functional consequences of ZNF217 alterations remain unknown, we comprehensively evaluated their impact in PMBCL. Targeted sequencing identified genetic lesions affecting ZNF217 in 33% of 157 PMBCL patients. Subsequent gene expression profiling...
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