Article

FBXW7β isoform drives transcriptional activation of a proinflammatory TNF cluster in normal and malignant pro-B cells

2022-04-25

Abstract excerpt

Non-canonical exon usage plays many important roles in cellular phenotypes, but its contribution to human B-cell development remains sketchily understood. To fill this gap, we collected various B-cell fractions from bone marrow and tonsil donors, performed RNA-seq, and examined transcript variants. We identified 150 genes that harbor local splicing variations in all pairwise comparisons. One of them encodes FBXW7,...

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Identifiers and source

Literature Corpus work: 36e26896-768c-5bfa-862e-7c32f2f171fa
DOI: 10.1101/2022.04.24.489313

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