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Article

Transcriptional reprogramming by mutated IRF4 in lymphoma

7 Nov 2023

Abstract excerpt

Disease-causing mutations in genes encoding transcription factors (TFs) can affect TF interactions with their cognate DNA-binding motifs. Whether and how TF mutations impact upon the binding to TF composite elements (CE) and the interaction with other TFs is unclear. Here, we report a distinct mechanism of TF alteration in human lymphomas with perturbed B cell identity, in particular classic Hodgkin lymphoma. It...

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PMID: 37935654
DOI: 10.1038/s41467-023-41954-8

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