Article
An in-depth association analysis of genetic variants within nicotine-related loci: Meeting in middle of GWAS and genetic fine-mapping.
Molecular and cellular neurosciences - 1 Dec 2023
Mo Chen, Ye Zhenyao, Pan Yezhi, Zhang Yuan, Wu Qiong, Bi Chuan, Liu Song, Mitchell Braxton, Kochunov Peter, Hong L Elliot, Ma Tianzhou, Chen Shuo
Abstract excerpt
In the last two decades of Genome-wide association studies (GWAS), nicotine-dependence-related genetic loci (e.g., nicotinic acetylcholine receptor - nAChR subunit genes) are among the most replicable genetic findings. Although GWAS results have reported tens of thousands of SNPs within these loci, further analysis (e.g., fine-mapping) is required to identify the causal variants. However, it is computationally...
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