Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

APOBEC mutagenesis is a common process in normal human small intestine

26 Jan 2023

Abstract excerpt

APOBEC mutational signatures SBS2 and SBS13 are common in many human cancer types. However, there is an incomplete understanding of its stimulus, when it occurs in the progression from normal to cancer cell and the APOBEC enzymes responsible. Here we whole-genome sequenced 342 microdissected normal epithelial crypts from the small intestines of 39 individuals and found that SBS2/SBS13 mutations were present in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Genetic factors in colorectal cancer
Share to Renal and related cancers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36702998
DOI: 10.1038/s41588-022-01296-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

APOBEC mutagenesis is a common process in normal human small intestinePMID 36702998Read ↗

Mutational signatures in human small intestinal crypts indicate APOBEC mutagenesis.Semantic proximity Read ↗

The landscape of somatic mutation in normal colorectal epithelial cellsSemantic proximity Read ↗

High-depth Whole Genome Sequencing of Single Human Colon Crypts Uncovers New View on Crypt ClonalitySemantic proximity Read ↗

The landscape of somatic mutation in normal colorectal epithelial cells.Semantic proximity Read ↗

Single-crypt evolutionary trajectories of human sporadic and hereditary colorectal precancersSemantic proximity Read ↗

Early mutational events and clonal dynamics in normal crypts: implications for colorectal tumorigenesis.Semantic proximity Read ↗

APOBEC3B, a molecular driver of mutagenesis in human cancersSemantic proximity Read ↗

Large chromosome deletions, duplications, and gene conversion events accumulate with age in normal human colon cryptsSemantic proximity Read ↗

APOBEC-Induced Mutagenesis in Cancer.Semantic proximity Read ↗

APOBEC3-mediated mutagenesis in cancer: causes, clinical significance and therapeutic potential.Semantic proximity Read ↗

Exome-wide somatic mutation characterization of small bowel adenocarcinoma.Semantic proximity Read ↗

Stem cells as common ancestors in a colorectal cancer ancestral tree.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.