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Article

Targeted NGS on sequential bone marrow biopsies aids in the evaluation of cytopenias and monocytosis and documents clonal evolution-a proof of principle study.

Virchows Archiv : an international journal of pathology - 1 Dec 2023

Nann Dominik, Rau Achim, Mahmutovic Lejla, Steinhilber Julia, Meca Vanessa, Federmann Birgit, Vogel Wichard, Bonzheim Irina, Quintanilla-Martinez Leticia, Fend Falko

Abstract excerpt

Differential diagnosis of clonal versus reactive cytopenia and monocytosis, respectively, frequently presents a diagnostic challenge. With the two recent classifications of myeloid disorders, mutational analysis has gained importance as a diagnostic tool. However, reports on its utility on trephine bone marrow biopsies (BMB) are sparse. The aim of our proof of principle study was to determine the suitability of...

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Identifiers

PMID: 37610626
DOI: 10.1007/s00428-023-03627-1
PMCID: PMC10700460

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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