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Pharmacokinetic, Pharmacodynamic and Pharmacogenetic Studies Related to Vincristine-Induced Peripheral Neuropathy in Chinese Pediatric ALL Patients.

Clinical pharmacology and therapeutics - 1 Feb 2025

Yuan Yawen, Hu Wenting, Chen Changcheng, Yao Ruen, Zhang Shunguo, Zhu Xiao, Xu Bulong, Huang Zhonghui, Zhang Shengyuan, Wang Xuexian, Zheng Mei, Huang Xiaohui, Standing Joseph F

Abstract excerpt

Vincristine (VCR) can cause vincristine-induced peripheral neuropathy (VIPN) during the treatment of acute lymphoblastic leukemia (ALL) and the mechanisms are complicated. The aim of this study was to investigate the influencing factors on the population pharmacokinetics (PopPK) and pharmacodynamics (PD) related to VIPN, including clearance routes, drug-drug interactions (DDI), and genetic characteristics....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 39367622
DOI: 10.1002/cpt.3462

Genes

ABCB1
CEP72
CYP3A4
CYP3A5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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