Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Apparent high CYP3A5 expression is required for significant metabolism of vincristine by human cryopreserved hepatocytes.

The Journal of pharmacology and experimental therapeutics - 1 Oct 2008

Dennison Jennifer B, Mohutsky Michael A, Barbuch Robert J, Wrighton Steven A, Hall Stephen D

Abstract excerpt

Vincristine is metabolized to one primary metabolite, M1, by cDNA-expressed CYP3A4 and CYP3A5 and by CYP3A enzymes in human liver microsomes. For both systems, CYP3A5 is predicted to mediate approximately 80% of the CYP3A metabolism for individuals with high CYP3A5 expression (at least one CYP3A5...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents, Phytogenic
Share to Cryopreservation
Share to Cytochrome P-450 CYP3A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP3A Inhibitors

Share to Hepatocytes

Share to Metabolic Clearance Rate

Share to Steroid Hydroxylases

Share to Vincristine

Source

Identifiers

PMID: 18650247
DOI: 10.1124/jpet.108.139998

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18650247-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Apparent high CYP3A5 expression is required for significant metabolism of vincristine by human cryopreserved hepatocytes.PMID 18650247Read ↗

Effect of CYP3A5 expression on vincristine metabolism with human liver microsomes.Semantic proximity Read ↗

Effect of Cytochrome b5 Content on the Activity of Polymorphic CYP1A2, 2B6, and 2E1 in Human Liver Microsomes.Semantic proximity Read ↗

Determination of a quantitative relationship between hepatic CYP3A5*1/*3 and CYP3A4 expression for use in the prediction of metabolic clearance in virtual populations.Semantic proximity Read ↗

Increased risk of vincristine neurotoxicity associated with low CYP3A5 expression genotype in children with acute lymphoblastic leukemia.Semantic proximity Read ↗

Influence of CYP3A5 and ABCB1 polymorphisms on the pharmacokinetics of vincristine in adult patients receiving CHOP therapy.Semantic proximity Read ↗

Effect of CYP3A5 expression on the inhibition of CYP3A-catalyzed drug metabolism: impact on modeling CYP3A-mediated drug-drug interactions.Semantic proximity Read ↗

CYP4F2 is a vitamin K1 oxidase: An explanation for altered warfarin dose in carriers of the V433M variant.Semantic proximity Read ↗

Vincristine Disposition and Neurotoxicity Are Unchanged in Humanized CYP3A5 Mice.Semantic proximity Read ↗

In vitro metabolism of cyclosporine A by human kidney CYP3A5.Semantic proximity Read ↗

The influence of CYP3A5 expression on the extent of hepatic CYP3A inhibition is substrate-dependent: an in vitro-in vivo evaluation.Semantic proximity Read ↗

In vitro studies on the metabolism of trabectedin (YONDELIS) in monkey and man, including human CYP reaction phenotyping.Semantic proximity Read ↗

Cytochrome P450 3A5 plays a prominent role in the oxidative metabolism of the anti-human immunodeficiency virus drug maraviroc.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.