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Article

Effects of cytochrome P450 family 3 subfamily A member 5 gene polymorphisms on daunorubicin metabolism and adverse reactions in patients with acute leukemia.

Molecular medicine reports - 1 Jun 2017

Huang Zhen, Wang Juxiang, Qian Jiangchao, Li Yuan, Xu Zhisheng, Chen Min, Tong Hongfei

Abstract excerpt

The present study aimed to investigate the association between the genetic polymorphism of cytochrome P450 family 3 subfamily A member 5 (CYP3A5) and the activity of CYP3A and plasma concentrations of daunorubicin (DNR) in patients with acute leukemia. A total of 36 children with newly diagnosed acute lymphoblastic leukemia were enrolled in the study. Polymerase chain reaction (PCR)‑restriction fragment length...

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Identifiers

PMID: 28440407
DOI: 10.3892/mmr.2017.6470
PMCID: PMC5436286

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