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Article

Diffusion Magnetic Resonance Imaging of Cortical Microstructure Differs in Nonmanifest and Manifest Genetic Parkinson's Disease.

Movement disorders : official journal of the Movement Disorder Society - 1 Jul 2026

Torso Mario, Tzaferou Dimitra, Valotti Michele, Hardwidge Jamie, Hardingham Ian, Koychev Ivan, Guo Qi, Comley Robert, Chance Steven A, Ridgway Gerard R

Abstract excerpt

BACKGROUND: Previous investigations into neurodegenerative diseases demonstrated the utility of cortical diffusivity metrics in assessing microstructural changes. OBJECTIVE: The objective of this study was to explore cortical diffusivity metrics in genetic Parkinson's disease (PD) with glucocerebrosidase 1 (GBA1) and Leucine-rich repeat kinase 2 (LRRK2) mutations, encompassing both nonmanifest carriers (NMCs) and...

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Identifiers

PMID: 41978242
DOI: 10.1002/mds.70298
PMCID: PMC13387919

Genes

GBA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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