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Article

Electrochemical Nanoreactor Provides a Comprehensive View of Isocitrate Dehydrogenase Cancer-drug Kinetics.

Angewandte Chemie (International ed. in English) - 16 Oct 2023

Herold Ryan A, Schofield Christopher J, Armstrong Fraser A

Abstract excerpt

The ability to control enzyme cascades entrapped in a nanoporous electrode material (the "Electrochemical Leaf", e-Leaf) has been exploited to gain detailed kinetic insight into the mechanism of an anti-cancer drug. Ivosidenib, used to treat acute myeloid leukemia, acts on a common cancer-linked variant of isocitrate dehydrogenase 1 (IDH1 R132H) inhibiting its "gain-of-function" activity-the undesired reduction...

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Identifiers

PMID: 37607127
DOI: 10.1002/anie.202309149
PMCID: PMC10962598

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