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Article

Exploiting Electrode Nanoconfinement to Investigate the Catalytic Properties of Isocitrate Dehydrogenase (IDH1) and a Cancer-Associated Variant.

The journal of physical chemistry letters - 8 Jul 2021

Herold Ryan A, Reinbold Raphael, Megarity Clare F, Abboud Martine I, Schofield Christopher J, Armstrong Fraser A

Abstract excerpt

Human isocitrate dehydrogenase (IDH1) and its cancer-associated variant (IDH1 R132H) are rendered electroactive through coconfinement with a rapid NADP(H) recycling enzyme (ferredoxin-NADP+ reductase) in nanopores formed within an indium tin oxide electrode. Efficient coupling to localized NADP(H) enables IDH activity to be energized, controlled, and monitored in real time, leading directly to a thermodynamic...

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Identifiers

PMID: 34170697
DOI: 10.1021/acs.jpclett.1c01517
PMCID: PMC8273889

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