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Article

Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1.

The Journal of biological chemistry - 16 May 2014

Davis Mindy I, Gross Stefan, Shen Min, Straley Kimberly S, Pragani Rajan, Lea Wendy A, Popovici-Muller Janeta, DeLaBarre Byron, Artin Erin, Thorne Natasha, Auld Douglas S, Li Zhuyin, Dang Lenny, Boxer Matthew B, Simeonov Anton

Abstract excerpt

Two mutant forms (R132H and R132C) of isocitrate dehydrogenase 1 (IDH1) have been associated with a number of cancers including glioblastoma and acute myeloid leukemia. These mutations confer a neomorphic activity of 2-hydroxyglutarate (2-HG) production, and 2-HG has previously been implicated as...

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Identifiers

PMID: 24668804
DOI: 10.1074/jbc.M113.511030
PMCID: PMC4022846

Genes

IDH1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24668804-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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