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Article

Electrochemiluminescent Detection of hNQO1 and Associated Drug Screening Enabled by Futile Redox Cycle Reaction

2020-02-18

Abstract excerpt

Human NAD(P)H: quinone oxidoreductase 1 (hNQO1), a proteinase that engages in detoxification of quinones and capable of activating anti-tumor drugs, has drawn increasing attention as tumor biomarker and drug target. To date, the detection of hNQO1 primarily uses stimulus-responsive probes, involving metabolization of synthetic quinone-functionalized substrates, which however, remain challenging to improve the...

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Literature Corpus work
eba10391-d623-52e2-91d4-75bcb4197b4d
DOI
10.26434/chemrxiv.11852763.v1
Open publication

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Electrochemiluminescent Detection of hNQO1 and Associated Drug Screening Enabled by Futile Redox Cycle ReactionDOI 10.26434/chemrxiv.11852763.v1
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