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Gaining Insight into the Catalytic Mechanism of the R132H IDH1 Mutant: A Synergistic DFT Cluster and Experimental Investigation.

Biochemistry - 15 Oct 2024

Broome Joshua A, Nguyen Nguyen P, Baumung Cassidy R E, Chen Vincent C, Bushnell Eric A C

Abstract excerpt

Human isocitrate dehydrogenase 1 (IDH1) is an enzyme that is found in humans that plays a critical role in aerobic metabolism. As a part of the citric acid cycle, IDH1 becomes responsible for catalyzing the oxidative decarboxylation of isocitrate to form α-ketoglutarate (αKG), with nicotinamide adenine dinucleotide phosphate (NADP+) as a cofactor. Strikingly, mutations of the IDH1 enzyme have been discovered in...

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PMID: 39318042
DOI: 10.1021/acs.biochem.4c00022

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