Article

The development and application of an engineered direct electron transfer enzyme for continuous levodopa monitoring

2024-11-18

Abstract excerpt

<title>Abstract</title> Levodopa, the primary treatment for Parkinson's Disease, has a narrow therapeutic window further complicated by the lack of real-time feedback, primarily due to the absence of an enzyme specific to levodopa. We addressed this by developing a novel direct electron transfer type(DET) enzyme, copper dehydrogenase (CoDH), engineered from an extremophile derived multicopper oxidase (MCO), fo...

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Literature Corpus work: ad1bc359-ecca-5097-8c2b-557769dd6ab5
DOI: 10.21203/rs.3.rs-5080384/v1

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