Article
A cross-species transcriptomic analysis reveals a novel 2-dimensional classification system explaining the invasiveness heterogeneity of pancreatic neuroendocrine tumor.
Cancer letters - 28 Feb 2025
Hong Xiafei, Zhang Xingwu, Jiang Rui, Qiao Sitan, Wang Wenze, Zhang Hao, Wang Jingqiao, Yin Bohui, Li Fuqiang, Ling Chao, Wang Xianze, Zhao Yupei, Wu Kui, Wu Wenming
Abstract excerpt
Pancreatic neuroendocrine tumors (PanNETs), the second most common type of primary pancreatic tumors, display notable heterogeneity in invasiveness. Current knowledge regarding genomic alterations, including DAXX/ATRX, MEN1 mutations, and copy number variations (CNVs), provides some insights into tumor invasiveness. However, the underlying reasons for the significant variation in invasiveness between insulinoma...
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