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Somatic rearrangements causing oncogenic ectodomain deletions of FGFR1 in squamous cell lung cancer

22 Aug 2023

Abstract excerpt

The discovery of frequent 8p11-p12 amplifications in squamous cell lung cancer (SQLC) has fueled hopes that FGFR1, located inside this amplicon, might be a therapeutic target. In a clinical trial, only 11% of patients with 8p11 amplification (detected by FISH) responded to FGFR kinase inhibitor treatment. To understand the mechanism of FGFR1 dependency, we performed deep genomic characterization of 52 SQLCs with...

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PMID: 37606995
DOI: 10.1172/jci170217

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