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Article

FGFR rearrangements: oncogenic drivers and therapeutic targets.

Trends in cancer - 1 May 2026

Yemelyanenko Julia, Jonkers Jos, Zingg Daniel

Abstract excerpt

Genomic amplifications and hotspot mutations affecting fibroblast growth factor receptors (FGFRs) have long been recognized as oncogenic drivers across human cancers. However, recent studies have uncovered FGFR in-frame fusions and complex structural variants as an additional class of tumor driver alterations. Notably, the identification of FGFR2 exon 18 truncations and the demonstration of their potent oncogenic...

Topics

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Receptor, Fibroblast Growth Factor, Type 2
Receptors, Fibroblast Growth Factor
Carcinogenesis
Gene Rearrangement
Molecular Targeted Therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oncogene Proteins, Fusion

Precision Medicine

Protein Kinase Inhibitors

Source

Identifiers

PMID: 41781241
DOI: 10.1016/j.trecan.2026.01.010

Genes

FGFR2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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