Article
Inhibitor-sensitive FGFR2 and FGFR3 mutations in lung squamous cell carcinoma.
Cancer research - 15 Aug 2013
Liao Rachel G, Jung Joonil, Tchaicha Jeremy, Wilkerson Matthew D, Sivachenko Andrey, Beauchamp Ellen M, Liu Qingsong, Pugh Trevor J, Pedamallu Chandra Sekhar, Hayes D Neil, Gray Nathanael S, Getz Gad, Wong Kwok-Kin, Haddad Robert I, Meyerson Matthew, Hammerman Peter S
Abstract excerpt
A comprehensive description of genomic alterations in lung squamous cell carcinoma (lung SCC) has recently been reported, enabling the identification of genomic events that contribute to the oncogenesis of this disease. In lung SCC, one of the most frequently altered receptor tyrosine kinase families is the fibroblast growth factor receptor (FGFR) family, with amplification or mutation observed in all four family...
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