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Article

Oncofusions - shaping cancer care.

The oncologist - 17 Jan 2025

Dashi Giovanna, Varjosalo Markku

Abstract excerpt

Cancer manifests through a spectrum of mutations, including gene fusions termed oncofusions. These structural alterations influence tumorigenesis across various cancer types. Oncofusions arise primarily from genomic rearrangements and operate through deregulation or hybrid gene formation mechanisms. Notable examples such as BCR::ABL and EWS::FLI1 underscore their clinical significance. Several case studies...

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Identifiers

PMID: 38833619
DOI: 10.1093/oncolo/oyae126
PMCID: PMC11783282

Genes

BCR
FLI1

Provenance

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