Article
Examining clustered somatic mutations with SigProfilerClusters.
Bioinformatics (Oxford, England) - 27 Jun 2022
Bergstrom Erik N, Kundu Mousumy, Tbeileh Noura, Alexandrov Ludmil B
Abstract excerpt
MOTIVATION: Clustered mutations are found in the human germline as well as in the genomes of cancer and normal somatic cells. Clustered events can be imprinted by a multitude of mutational processes, and they have been implicated in both cancer evolution and development disorders. Existing tools for identifying clustered mutations have been optimized for a particular subtype of clustered event and, in most cases,...
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